Genome Science of Vertebrate
نویسندگان
چکیده
1. The Importance of the Mouse Genome and Transcriptome Study 2. The History of Mouse Genetics 2.1. The Beginning of Mouse Genetics and the Establishment of Inbred Strains 3. The Determination of Mouse Genome Sequences 4. A Full-Length Mouse cDNA Project 4.1. From the EST Project to the Full-Length cDNA Project 4.2. Findings from Genome and cDNA Sequences 4.3. Functional Annotation of Mouse cDNA Sequences 5. Positional Cloning 6. cDNA Encyclopedia and the Positional Candidate Approach 7. Functional Genomics 7.1. DNA Microarray 7.2. PPI and PDI (Protein–Protein Interaction, Protein–DNA Interaction) 7.3. Structural Genomics Glossary Bibliography Biographical Sketches
منابع مشابه
Predicting CpG Islands and Their Relationship with Genomic Feature in Cattle by Hidden Markov Model Algorithm
Cattle supply an important source of nutrition for humans in the world. CpG islands (CGIs) are very important and useful, as they carry functionally relevant epigenetic loci for whole genome studies. As a matter of fact, there have been no formal analyses of CGIs at the DNA sequence level in cattle genomes and therefore this study was carried out to fill the gap. We used hidden markov model alg...
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The human genome project has been recently complemented by whole-genome assessment sequence of 32 mammals and 24 nonmammalian vertebrate species suitable for comparative genomic analyses. Here we anticipate a precipitous drop in costs and increase in sequencing efficiency, with concomitant development of improved annotation technology and, therefore, propose to create a collection of tissue and...
متن کاملGenome 10K: a proposal to obtain whole-genome sequence for 10,000 vertebrate species.
The human genome project has been recently complemented by whole-genome assessment sequence of 32 mammals and 24 nonmammalian vertebrate species suitable for comparative genomic analyses. Here we anticipate a precipitous drop in costs and increase in sequencing efficiency, with concomitant development of improved annotation technology and, therefore, propose to create a collection of tissue and...
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Previous genome comparisons have suggested that one important trend in vertebrate evolution has been a sharp rise in intron abundance. By using genomic data and expressed sequence tags from the marine annelid Platynereis dumerilii, we provide direct evidence that about two-thirds of human introns predate the bilaterian radiation but were lost from insect and nematode genomes to a large extent. ...
متن کاملGenome 10 K : A Proposal to Obtain Whole - Genome Sequence for 10 000 Vertebrate Species
The human genome project has been recently complemented by whole-genome assessment sequence of 32 mammals and 24 nonmammalian vertebrate species suitable for comparative genomic analyses. Here we anticipate a precipitous drop in costs and increase in sequencing efficiency, with concomitant development of improved annotation technology and, therefore, propose to create a collection of tissue and...
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Recently genetic studies have been revolutionized by next generation sequencing (NGS) technology, and it is expected that the use of this technology will largely eliminate defects in the methods of association studies. The NGS technology is becoming the premier tool in genetics. However, at the moment the use of this method is limited especially in the livestock due to high cost and computation...
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